GE11 Proteínas redox en procesos fisiopatológicos

Autores/as: 1

Título: Lagal DJ, Ortiz-Alcántara Á, Pedrajas JR, McDonagh B, Bárcena JA, Requejo- Aguilar R, Padilla CA

Revista: Loss of peroxiredoxin 6 (PRDX6) alters lipid composition and distribution resulting in increased sensitivity to ferroptosis

DOI: 10.1042/BCJ20240445

IF: 4.4

1. Lagal DJ, Ortiz-Alcántara Á, Pedrajas JR, McDonagh B, Bárcena JA, Requejo- Aguilar R, Padilla CA. Loss of peroxiredoxin 6 (PRDX6) alters lipid composition and distribution resulting in increased sensitivity to ferroptosis. Biochem J. 2024 Nov 27:BCJ20240445. doi: 10.1042/BCJ20240445. IF: 4.4 Q2 D2

Autores/as: 2

Título: Papadas A, Lagal DJ, Dou Y, Hong D, Gibbons A, Cicala A, Huang Y, Zomalan B, Molina E, Asimakopoulos F

Revista: Protocol to identify and isolate rare murine tumor- resident dendritic cell populations for low-input transcriptomic profiling

DOI: 10.1016/j.xpro.2024.103195

IF: 1.3

2. Papadas A, Lagal DJ, Dou Y, Hong D, Gibbons A, Cicala A, Huang Y, Zomalan B, Molina E, Asimakopoulos F. Protocol to identify and isolate rare murine tumor- resident dendritic cell populations for low-input transcriptomic profiling. STAR Protoc. 2024 Sep 20;5(3):103195. doi: 10.1016/j.xpro.2024.103195. IF: 1.3 Q4 D4

Autores/as: 3

Título: Lagal DJ, Montes-Osuna AM, Ortiz-Olivencia A, Arribas-Parejas C, Ortiz- Alcántara Á, Pescuezo-Castillo C, Bárcena JA, Padilla CA, Requejo-Aguilar R

Revista: Tumoral Malignancy Decreases Coupled with Higher ROS and Lipid Peroxidation in HCT116 Colon Cancer Cells upon Loss of PRDX6

DOI: 10.3390/antiox13070881

IF: 6.0

3. Lagal DJ, Montes-Osuna AM, Ortiz-Olivencia A, Arribas-Parejas C, Ortiz- Alcántara Á, Pescuezo-Castillo C, Bárcena JA, Padilla CA, Requejo-Aguilar R. Tumoral Malignancy Decreases Coupled with Higher ROS and Lipid Peroxidation in HCT116 Colon Cancer Cells upon Loss of PRDX6. Antioxidants (Basel). 2024 Jul 22;13(7):881. doi: 10.3390/antiox13070881. IF: 6.0 Q1 D2

Autores/as: Publicaciones principales de los últimos 5 años

Publicaciones principales de los últimos 5 años

Autores/as: 1

Título: Lagal DJ, Ortiz-Alcántara Á, Pedrajas JR, McDonagh B, Bárcena JA, Requejo- Aguilar R, Padilla CA

Revista: Loss of peroxiredoxin 6 (PRDX6) alters lipid composition and distribution resulting in increased sensitivity to ferroptosis

DOI: 10.1042/BCJ20240445

IF: 4.4

1. Lagal DJ, Ortiz-Alcántara Á, Pedrajas JR, McDonagh B, Bárcena JA, Requejo- Aguilar R, Padilla CA. Loss of peroxiredoxin 6 (PRDX6) alters lipid composition and distribution resulting in increased sensitivity to ferroptosis. Biochem J. 2024 Nov 27:BCJ20240445. doi: 10.1042/BCJ20240445. IF: 4.4

Autores/as: 2

Título: Lagal DJ, Montes-Osuna AM, Ortiz-Olivencia A, Arribas-Parejas C, Ortiz- Alcántara Á, Pescuezo-Castillo C, Bárcena JA, Padilla CA, Requejo-Aguilar R

Revista: Tumoral Malignancy Decreases Coupled with Higher ROS and Lipid Peroxidation in HCT116 Colon Cancer Cells upon Loss of PRDX6

DOI: 10.3390/antiox13070881

IF: 6

2. Lagal DJ, Montes-Osuna AM, Ortiz-Olivencia A, Arribas-Parejas C, Ortiz- Alcántara Á, Pescuezo-Castillo C, Bárcena JA, Padilla CA, Requejo-Aguilar R. Tumoral Malignancy Decreases Coupled with Higher ROS and Lipid Peroxidation in HCT116 Colon Cancer Cells upon Loss of PRDX6. Antioxidants (Basel). 2024 Jul 22;13(7):881. doi: 10.3390/antiox13070881. IF: 6

Autores/as: 3

Título: Requejo-Aguilar R

Revista: Cdk5 and aberrant cell cycle activation at the core of neurodegeneration

DOI: 10.4103/1673-5374.360165

IF: 5.9

3. Requejo-Aguilar R. Cdk5 and aberrant cell cycle activation at the core of neurodegeneration. Neural Regen Res. 2023 Jun;18(6):1186-1190. doi: 10.4103/1673-5374.360165. IF: 5.9

Autores/as: 4

Título: Lagal DJ, López-Grueso MJ, Pedrajas JR, Leto TL, Bárcena JA, Requejo-Aguilar R, Padilla CA

Revista: Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines

DOI: 10.3390/antiox12061153

IF: 6

4. Lagal DJ, López-Grueso MJ, Pedrajas JR, Leto TL, Bárcena JA, Requejo-Aguilar R, Padilla CA. Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines. Antioxidants (Basel). 2023 May 25;12(6):1153. doi: 10.3390/antiox12061153. IF: 6

Autores/as: 5

Título: Lagal DJ, Bárcena JA, Requejo-Aguilar R, Padilla CA, Leto TL

Revista: NOX1 and PRDX6 synergistically support migration and invasiveness of hepatocellular carcinoma cells through enhanced NADPH oxidase activity

DOI: 10.1016/j.arres.2023.100080

5. Lagal DJ, Bárcena JA, Requejo-Aguilar R, Padilla CA, Leto TL. NOX1 and PRDX6 synergistically support migration and invasiveness of hepatocellular carcinoma cells through enhanced NADPH oxidase activity. Adv Redox Res. 2023 Dec;9:100080. doi: 10.1016/j.arres.2023.100080.

Autores/as: 6

Título: López-Grueso MJ, Padilla CA, Bárcena JA, Requejo-Aguilar R

Revista: Deficiency of Parkinson's Related Protein DJ-1 Alters Cdk5 Signalling and Induces Neuronal Death by Aberrant Cell Cycle Re-entry

DOI: 10.1007/s10571-022-01206-7

IF: 3.6

6. López-Grueso MJ, Padilla CA, Bárcena JA, Requejo-Aguilar R. Deficiency of Parkinson's Related Protein DJ-1 Alters Cdk5 Signalling and Induces Neuronal Death by Aberrant Cell Cycle Re-entry. Cell Mol Neurobiol. 2023 Mar;43(2):757-769. doi: 10.1007/s10571-022-01206-7. IF: 3.6

Autores/as: 7

Título: C Picazo, CA Padilla, B McDonagh, E Matallana, JA Bárcena & A Aranda

Revista: Regulation of metabolism, stress response, and sod1 activity by cytosolic thioredoxins in yeast depends on growth phase

DOI: 10.1016/j.arres.2023.100081

7. C Picazo, CA Padilla, B McDonagh, E Matallana, JA Bárcena & A Aranda. Regulation of metabolism, stress response, and sod1 activity by cytosolic thioredoxins in yeast depends on growth phase. Adv Redox Res. 2023, 9-100081, doi: 10.1016/j.arres.2023.100081.

Autores/as: 8

Título: Giraldo E, Nebot VJ, Đorđević S, Requejo-Aguilar R, Alastrue-Agudo A, Zagorodko O, Armiñan A, Martinez-Rojas B, Vicent MJ, Moreno-Manzano V

Revista: A rationally designed self-immolative linker enhances the synergism between a polymer-rock inhibitor conjugate and neural progenitor cells in the treatment of spinal cord injury

DOI: 10.1016/j.biomaterials.2021.121052

IF: 15.3

8. Giraldo E, Nebot VJ, Đorđević S, Requejo-Aguilar R, Alastrue-Agudo A, Zagorodko O, Armiñan A, Martinez-Rojas B, Vicent MJ, Moreno-Manzano V. A rationally designed self-immolative linker enhances the synergism between a polymer-rock inhibitor conjugate and neural progenitor cells in the treatment of spinal cord injury. Biomaterials. 2021 Sep;276:121052. doi: 10.1016/j.biomaterials.2021.121052. IF: 15.3

Autores/as: 9

Título: López-Grueso MJ, Lagal DJ, García-Jiménez ÁF, Tarradas RM, Carmona-Hidalgo B, Peinado J, Requejo-Aguilar R, Bárcena JA, Padilla CA

Revista: Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells

DOI: 10.1016/j.redox.2020.101737

IF: 11.8

9. López-Grueso MJ, Lagal DJ, García-Jiménez ÁF, Tarradas RM, Carmona-Hidalgo B, Peinado J, Requejo-Aguilar R, Bárcena JA, Padilla CA. Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. Redox Biol. 2020 Oct;37:101737. doi: 10.1016/j.redox.2020.101737. IF: 11.8

Autores/as: 10

Título: Martina, J

Revista: A

DOI: 10.15252/embj.2020105793

IF: 11.6

10. Martina, J.A., D. Guerrero-Gómez, E. Gómez-Orte, J.A. Bárcena, J. Cabello, A. Miranda-Vizuete, and R. Puertollano. A conserved cysteine-based redox mechanism sustains TFEB/HLH-30 activity under persistent stress. EMBO J. 2020; doi:10.15252/embj.2020105793. IF: 11.6

Autores/as: 11

Título: Rodríguez-Hernández MA, de la Cruz-Ojeda P, López-Grueso MJ, Navarro-Villarán E, Requejo-Aguilar R, Castejón-Vega B, Negrete M, Gallego P, Vega-Ochoa Á, Victor VM, Cordero MD, Del Campo JA, Bárcena JA, Padilla CA, Muntané J

Revista: Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer

DOI: 10.1016/j.redox.2020.101510

IF: 11.8

11. Rodríguez-Hernández MA, de la Cruz-Ojeda P, López-Grueso MJ, Navarro-Villarán E, Requejo-Aguilar R, Castejón-Vega B, Negrete M, Gallego P, Vega-Ochoa Á, Victor VM, Cordero MD, Del Campo JA, Bárcena JA, Padilla CA, Muntané J. Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer. Redox Biol. 2020 Sep;36:101510. doi: 10.1016/j.redox.2020.101510. IF: 11.8

Autores/as: 12

Título: R González, MA Rodríguez-Hernández, M Negrete & J Muntané

Revista: Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer

IF: 11,799

12. R González, MA Rodríguez-Hernández, M Negrete & J Muntané. Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer. Redox Biol. 2020; 34-101528, doi.org/10.1016/j.redox.2020.101528. IF: 11,799.

Autores/as: 13

Título: López Grueso MJ, Tarradas Valero RM, Carmona-Hidalgo B, Lagal Ruiz DJ, Peinado J, McDonagh B, Requejo Aguilar R, Bárcena Ruiz JA, Padilla Peña CA

Revista: Peroxiredoxin 6 Down-Regulation Induces Metabolic Remodeling and Cell Cycle Arrest in HepG2 Cells

DOI: 10.3390/antiox8110505

IF: 5

13. López Grueso MJ, Tarradas Valero RM, Carmona-Hidalgo B, Lagal Ruiz DJ, Peinado J, McDonagh B, Requejo Aguilar R, Bárcena Ruiz JA, Padilla Peña CA. Peroxiredoxin 6 Down-Regulation Induces Metabolic Remodeling and Cell Cycle Arrest in HepG2 Cells. Antioxidants (Basel). 2019 Oct 23;8(11):505. doi: 10.3390/antiox8110505. IF: 5

Autores/as: 14

Título: López-Grueso MJ, González-Ojeda R, Requejo-Aguilar R, McDonagh B, Fuentes- Almagro CA, Muntané J, Bárcena JA, Padilla CA

Revista: Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches

DOI: 10.1016/j.redox.2018.11.007

IF: 10

14. López-Grueso MJ, González-Ojeda R, Requejo-Aguilar R, McDonagh B, Fuentes- Almagro CA, Muntané J, Bárcena JA, Padilla CA. Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches. Redox Biol. 2019 Feb;21:101049. doi: 10.1016/j.redox.2018.11.007. IF: 10

Autores/as: 15

Título: Padilla CA, Bárcena JA, López-Grueso MJ, Requejo-Aguilar R

Revista: The regulation of TORC1 pathway by the yeast chaperones Hsp31 is mediated by SFP1 and affects proteasomal activity

DOI: 10.1016/j.bbagen.2018.12.011

IF: 3.42

15. Padilla CA, Bárcena JA, López-Grueso MJ, Requejo-Aguilar R. The regulation of TORC1 pathway by the yeast chaperones Hsp31 is mediated by SFP1 and affects proteasomal activity. Biochim Biophys Acta Gen Subj. 2019 Mar;1863(3):534-546. doi: 10.1016/j.bbagen.2018.12.011. IF: 3.42

Autores/as: Tesis dirigidas en los últimos 5 años

Tesis dirigidas en los últimos 5 años

Autores/as: Papel de peroxirredoxina 6 en la regulación redox de los procesos de proliferación y supervivencia celular

Título: En desarrollo

Revista: Universidad de Córdoba

Papel de peroxirredoxina 6 en la regulación redox de los procesos de proliferación y supervivencia celular. En desarrollo. Universidad de Córdoba.

Autores/as: Estudio de la función de peroxirredoxina 6 (PRDX6) en la pérdida neuronal asociada a la enfermedad de Parkinson

Título: En desarrollo

Revista: Universidad de Córdoba

Estudio de la función de peroxirredoxina 6 (PRDX6) en la pérdida neuronal asociada a la enfermedad de Parkinson. En desarrollo. Universidad de Córdoba.

Autores/as: Función de peroxirredoxina 6 y sus actividades peroxidasa y fosfolipasa A2 en la progresión tumoral de modelos de hepatocacinoma, y cáncer de colon

Título: En desarrollo

Revista: Universidad de Córdoba

Función de peroxirredoxina 6 y sus actividades peroxidasa y fosfolipasa A2 en la progresión tumoral de modelos de hepatocacinoma, y cáncer de colon. En desarrollo. Universidad de Córdoba.

Autores/as: Role of human Peroxiredoxin 6 (PRDX6) in proliferation, migration and invasiveness of hepatocarcinoma cell lines

Título: 2023

Revista: Universidad de Córdoba

Role of human Peroxiredoxin 6 (PRDX6) in proliferation, migration and invasiveness of hepatocarcinoma cell lines. 2023. Universidad de Córdoba.

Autores/as: Redox regulation of proteome, metabolism and signaling in hepatocarcinoma tumor cells

Título: 2019

Revista: Universidad de Córdoba

Redox regulation of proteome, metabolism and signaling in hepatocarcinoma tumor cells. 2019. Universidad de Córdoba.